KEGG   Homo sapiens (human): 3294
Entry
3294              CDS       T01001                                 
Symbol
HSD17B2, EDH17B2, HSD17, SDR9C2
Name
(RefSeq) hydroxysteroid 17-beta dehydrogenase 2
  KO
K13368  17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:1.1.1.62 1.1.1.239]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa01100  Metabolic pathways
hsa04913  Ovarian steroidogenesis
Module
hsa_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Network
nt06019  Steroid hormone biosynthesis
  Element
N01541  Testosterone biosynthesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    3294 (HSD17B2)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    3294 (HSD17B2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.62  17beta-estradiol 17-dehydrogenase
     3294 (HSD17B2)
    1.1.1.239  3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
     3294 (HSD17B2)
SSDB
Motif
Pfam: adh_short adh_short_C2 KR Ins_allergen_rp Epimerase DUF6056 DUF4131
Other DBs
NCBI-GeneID: 3294
NCBI-ProteinID: NP_002144
OMIM: 109685
HGNC: 5211
Ensembl: ENSG00000086696
UniProt: P37059
Position
16:82035253..82098534
AA seq 387 aa
MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL
FSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPG
AEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELL
LMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVT
MFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI
LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYD
YFAKRHFGQDKPMPRALRMPNYKKKAT
NT seq 1164 nt   +upstreamnt  +downstreamnt
atgagcactttcttctcggacacagcatggatctgcctggctgtccccacagtactatgt
gggacagtattttgcaaatacaagaagagctcagggcagctgtggagctggatggtctgc
ctggcaggcctctgtgcagtctgcctgctcatcctgtcccctttttggggcttgatcctc
ttctcggtgtcatgcttcctcatgtatacttacttatctggccaagaattgttacctgtg
gatcagaaggcagtcctggtgacaggtggtgattgcgggcttggccatgctttgtgcaag
tatctggatgagctgggcttcacggtatttgccggagttttgaatgaaaatggcccagga
gctgaggaattgcgaagaacctgctctccgcgcctctcggtgctccaaatggacatcacg
aagccagtgcagataaaagatgcttacagcaaggttgcagcaatgctgcaggacagagga
ctgtgggctgtgatcaacaatgctggggtgcttggctttccaactgatggggagcttctt
cttatgactgactacaaacaatgcatggccgtgaacttctttggaactgtggaggtcaca
aagacgtttttgcctcttcttagaaaatccaaagggaggctggtgaatgtcagcagcatg
ggaggaggggccccaatggaaaggctggcatcttatggctcatcaaaggcggctgtgacc
atgttctcatcagttatgagactggagctttccaagtggggaattaaagttgcttccatc
caacctggaggcttcctaacaaatatcgcaggcaccagtgacaagtgggaaaagctggag
aaggacattctggaccacctccccgctgaggtacaggaagactacggccaggactacatc
ttagcacagcggaatttcctcctattgatcaactcgttagccagcaaggacttctctccg
gtgctgcgggacatccagcatgctatcttggcgaagagcccttttgcctattacacgcca
gggaaaggcgcttacttgtggatctgccttgctcactatttgcctattggcatatatgat
tactttgctaaaagacattttggccaagacaagcccatgcccagagctctaagaatgcct
aactacaagaaaaaggccacctag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical substance (13)   
   KEGG COMPOUND (13)   
Chemical reaction (9)   
   KEGG ENZYME (2)   
   KEGG REACTION (7)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (8)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (19)   
   RefSeq(nuc) (3)   
   GenBank (8)   
   EMBL (8)   
Protein domain (7)   
   Pfam (7)   
All databases (85)   

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